S.E.M.I. – Side Effects May Include...

S.E.M.I. – Side Effects May Include... is an exhilarating action platformer that blends cooperative gameplay with elements of chaos and unpredictability. Players take on the roles of patients in a quirky clinic, experiencing the wild effects of experimental drugs while navigating through various puzzles and obstacles. Teamwork is crucial as you and your friends face off against bizarre staff members and each other, leading to chaotic situations that are sure to inspire laughter and challenges. With randomly generated levels and unique abilities tied to various pills, every play session promises new surprises and fun!

Two Horn Unicorn
Two Horn Unicorn
January 23, 2026
80 % Positive (35 reviews)

Features

Multiplayer

The game supports online co-op gameplay for up to four players, allowing for chaotic fun with friends.

Unique Abilities

Players can take pills that grant unpredictable abilities, adding a layer of strategy and surprise to the gameplay.

Randomly Generated Levels

Each escape attempt features randomly generated rooms with varying gravity and traps, ensuring every playthrough is unique.

Voice Chat

Communicate with your teammates through voice chat to strategize, sabotage, and help each other through challenges.

Character Customization

Unlock new costumes and decorations to personalize your characters for stylish escapes.

Key Features

Single-player
Online Co-op
Family Sharing

Frequently Asked Questions

What is the game about?

The game is about escaping from a zany clinic as patients who take experimental drugs, leading to chaotic and unpredictable outcomes.

Is S.E.M.I. a multiplayer game?

Yes, S.E.M.I. supports online co-op gameplay for up to four players.

What platforms is S.E.M.I. available on?

S.E.M.I. is available on Windows.

When will S.E.M.I. be released?

S.E.M.I. is scheduled for release on January 23, 2026.

Can I play S.E.M.I. solo?

Yes, the game offers both single-player and online co-op modes.

What are the system requirements for S.E.M.I.?

The minimum requirements include Windows 10, Intel Core i5 or Ryzen series, 8 GB RAM, and GTX 960 or AMD R9 290 graphics.

Genres

Tags

Co-op Platformer Physics Multiplayer Online Co-Op Surreal Third Person Character Customization Psychological Indie Funny Stylized Action 3D Comedy Beat 'em up Action Roguelike Logic Singleplayer Puzzle

System Requirements

Minimum

Os

Windows 10

Memory

8 GB RAM

Storage

3 GB available space

Graphics

GTX 960 or AMD R9 290

Requires

Requires a 64-bit processor and operating system

Processor

Intel Core i5 series or Ryzen series

Recommended

Os

Windows 11

Memory

8 GB RAM

Storage

3 GB available space

Graphics

GTX 1660 or RX6600

Requires

Requires a 64-bit processor and operating system

Processor

Intel Core i7 series or Ryzen series

Supported Languages

Language Interface Subtitles Audio
English
Russian
French
German
Spanish - Spain
Simplified Chinese
Portuguese - Brazil
Japanese
Korean

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